London, UK – In a new study led by Imperial College London in collaboration with a group from the University of Cambridge, researchers transplanted human brain cells into a mouse brain, and for the first time watched how they grew and connected to each other. This allowed the team to study the way human brain cells interact in a more natural environment than previously possible.
News & Commentaries
Kyoto, Japan – A key determinant of successful immunotherapies is immune cells targeting the pathology with high specificity. CiRA scientists are using iPS cell technology to make a large batch of immune cells for immunotherapies. However, retaining the antigen specificity remains a challenge. A new study by the CiRA Associate Professor Shin Kaneko laboratory reports a method that solves this problem.
St. Louis, MO, USA – Scientists hoping to develop better treatments for kidney disease have turned their attention to growing clusters of kidney cells in the lab. One day, so-called organoids – grown from human stem cells – may help repair damaged kidneys in people or be used to test drugs developed to fight kidney disease.
San Francisco, CA, USA – Immunotherapy can cure some cancers that until fairly recently were considered fatal. In addition to developing drugs that boost the immune system’s cancer-fighting abilities, scientists are becoming expert at manipulating a patient’s own immune cells, turning them into cancer-killing armies. But cancers have tricks to evade attack, so scientists are racing to outmaneuver cancer and boost the effectiveness of immune cell therapies.
Aurora, CO, USA – Think of energy metabolism like a party popper: Ripping something apart releases a bang. Most of your cells rip apart sugar to release the “bang” of energy. A University of Colorado Cancer Center (UCCC) study published today in the journal Cancer Cell shows that cancer stem cells switch from metabolizing sugar to metabolizing protein, or more precisely amino acids, which are the building blocks of protein.
Camrbidge, MA, USA – Researchers have developed a way to grow human heart tissue that can serve as a model for the upper chambers of the heart, known as the atria. The tissue, derived from human induced pluripotent stem cells (hiPCSs), beats, expresses genes, and responds to drugs in a manner similar to a real human atrium.
San Francisco, CA, USA – Currently, the only therapy for metabolic liver disease is an organ transplant. Tracy Grikscheit, MD, an attending physician and regenerative medicine scientist at Children's Hospital Los Angeles, hopes to change that reality. She has been awarded nearly $1.3 million by the California Institute of Regenerative Medicine (CIRM) to study stem cell therapy for liver failure.
Skokie, IL, USA – Douglas Melton, the President of the International Society for Stem Cell Research (ISSCR) and founding editor of StemBook, outlines in an open letter a new format for the ISSCR Annual Meeting 2019 offering new opportunities and expanded horizons.
New Brunswick, NJ, USA – Rutgers scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer's and Parkinson's diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries.
Durham, NC, USA – A study recently published in Stem Cells Translational Medicine (SCTM) describes a new cell therapy that shows promise in treating cirrhosis of the liver. The treatment, a combination of mesenchymal stem cells and induced bone marrow-derived macrophages, reduced fibrosis and promoted regeneration of cirrhosis-damaged liver in tests on mice.