News & Commentaries

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Genetically Encoded Sensor Isolates Hidden Leukemic Stem Cells

Genetically Encoded Sensor Isolates Hidden Leukemic Stem Cells
Cells express surface markers that help them escape most targeted therapies, TAU researchers say

Tel Aviv, Israel – All stem cells can multiply, proliferate and differentiate. Because of these qualities, leukemic stem cells are the most malignant of all leukemic cells. Understanding how leukemic stem cells are regulated has become an important area of cancer research. A team of Tel Aviv University (TAU) researchers have now devised a novel biosensor that can isolate and target leukemic stem cells. The research team, led by Dr. Michael Milyavsky of the Department of Pathology at TAU's Sackler School of Medicine, discuss their unique genetically encoded sensor and its ability to identify, isolate and characterize leukemic stem cells in a study published in Leukemia.

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Hematopoietic Stem Cells: Making Blood Thicker than Water

Hematopoietic Stem Cells: Making Blood Thicker than Water

Osaka, Japan – The body needs to create a continuous supply of blood cells to enter circulation. Blood cells have a wide variety of functions ranging from supplying oxygen to tissues, fighting infections, and enabling the blood to clot upon injury. Avoiding deficiency of these cells or their excessive proliferation must involve a strict regulatory mechanism, but much remains to be clarified about how this works.

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Utrecht Researchers Develop Mini Kidneys from Urine Cells

Utrecht Researchers Develop Mini Kidneys from Urine Cells

Utrecht, NL – Scientists from the Hubrecht Institute, Princess Máxima Center, Utrecht University and University Medical Center Utrecht have successfully created kidney organoids from urine cells. This could lead to a wide range of new treatments that are less onerous for kidney patients. The results of the research were published in Nature Biotechnology.

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Scientists Rejuvenate Stem Cells in the Aging Brain of Mice

Scientists Rejuvenate Stem Cells in the Aging Brain of Mice

Luxembourg, Luxembourg – Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and from the German Cancer Research Center (DKFZ) have been able to rejuvenate stem cells in the brain of aging mice. The revitalised stem cells improve the regeneration of injured or diseased areas in the brain of old mice. The researchers expect that their approach will provide fresh impetus in regenerative medicine and facilitate the development of stem cell therapies.

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Can We Repair the Brain? The Promise of Stem Cell Technologies for Treating Parkinson's Disease

JPD article news
Despite challenges, new advances in stem cell biology and genetic engineering show potential for better cell replacement therapies, say experts in a special supplement to JPD

Amsterdam, NL – Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson's disease in future. Writing in an open access special supplement the Journal of Parkinson's Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment.

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UMN Medical School Study Provides New Insight Into the Use of Cell Replacement Therapies to Treat Muscular Dystrophies

uni of minnesota news

Minneapolis, MN, USA – The University of Minnesota Medical School continues its legacy of advancing cell replacement therapies with a scientific breakthrough that highlights the promise of cell therapies for muscular dystrophy.

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Mayo Clinic Researchers Develop More Efficient System to Reprogram Stem Cells

mayo clinic news

Rochester, MN, USA – Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Mayo researchers now report that using the measles virus vector; they’ve trimmed that multi-vector process with four reprogramming factors down to a single “one cycle” vector process. They say the process is safe, stable, faster and usable for clinical translation. The findings appear in the journal Gene Therapy.

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