News & Commentaries

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Megakaryocytes Act As „Bouncers“ Restraining Cell Migration in the Bone Marrow

STEMBOOK: Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow

Würzburg, Germany — Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal Haematologica.

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Slug, A Stem Cell Regulator, Keeps Breast Cells Healthy by Promoting Repair of DNA Damage

STEMBOOK: Slug, a stem cell regulator, keeps breast cells healthy by promoting repair of DNA damage

Boston, MA — A new study published in Cell Reports found that a transcription factor called Slug serves as ‘command central’ for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage. The research team also discovered that Slug likely functions as a safeguard against age-related decline of breast stem cell function.

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World First: Homing Instinct Applied to Stem Cells Show Cells "Home" to Cardiac Tissue

[STEMBOOK] World first: Homing instinct applied to stem cells show cells 'home' to cardiac tissue
Scientists hijack bacteria's homing ability

Bristol, UK – In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK (1). To date, trials using stem cells, which are taken and grown from the patient or donor and injected into the patient's heart to regenerate damaged tissue, have produced promising results.

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Scientists Developing Way to Help Premature Babies Breathe Easier

StemBook: Scientists developing way to help premature babies breathe easier (stem cells)
Study points to possible cell therapy for bronchopulmonary dysplasia

Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death.

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Landmark Study Signals Shift in Thinking About Stem Cell Differentiation

StemBook: Landmark Study Signals Shift in Thinking About Stem Cell Differentiation (stem cells)

Tallahassee, FL, USA – A pioneering new study led by Florida State University (FSU) biologists could fundamentally change our understanding of how embryonic stem cells differentiate into specific cell types. The research, published today in the journal Stem Cell Reports, calls into question decades of scientific consensus about the behavior of embryonic stem cells as they transition to endoderm, a class of cell in animal embryos that gives rise to the digestive and respiratory systems.

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Dormant Neural Stem Cells in Fruit Flies Activate to Generate New Brain Cells

StemBook: Dormant Neural Stem Cells in Fruit Flies Activate to Generate New Brain Cells (stem cells)

Singapore, Singapore – How dormant neural stem cells in fruit flies are activated and generate new neurons is described in a new research study by Duke-NUS Medical School. The findings could potentially help people with brain injury or neuronal loss, if similar mechanisms apply in humans. Publishing in PLOS Biology, the research team, led by Associate Professor Wang Hongyan, Deputy Director of Duke-NUS’ Neuroscience and Behavioural Disorders Programme and lead author of the study, described the process and molecules involved in reactivating fruit flies’ (also known by their scientific name, Drosophila) dormant neural stem cells, which can activate and generate new neurons.

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Introduced a New Paradigm of Cell Transplantation with Scaffold Microrobots

StemBook: Introduced a New Paradigm of Cell Transplantation with Scaffold Microrobots (stem cells)

Daegu, Korea – A research team from Daegu Gyeongbuk Institute of Science and Technology (DGIST) succeeded in developing stem cell delivery of scaffold microrobot that can precisely deliver cells to a target body tissue. This research achievement is expected to enhance the treatment safety and efficiency of degenerative neural disorders as it can precisely transplant the exact amount of stem cell-based treatment cells to human body tissues and organs.

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