Papers of the Week

April 1 - April 7, 2019

Nuclear magnetic resonance spectroscopy to identify metabolite biomarkers of non-responsiveness to targeted therapy in glioblastoma tumor stem cells.

Hvinden, I.Comfort, Berg, H.Engen, Sachse, D., Skaga, E., Skottvoll, F.Sved, Lundanes, E., Sandberg, C.J., Vik-Mo, E.O., Rise, F., and Wilson, S.Ray (2019). Nuclear magnetic resonance spectroscopy to identify metabolite biomarkers of non-responsiveness to targeted therapy in glioblastoma tumor stem cells.J Proteome Res.

Bone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.

Chahal, J., Gomez-Aristizábal, A., Shestopaloff, K., Bhatt, S., Chaboureau, A., Fazio, A., Chisholm, J., Weston, A., Chiovitti, J., Keating, A., et al. (2019). Bone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.Stem Cells Transl Med.

Engineering three-dimensional microenvironments towards <i>in vitro</i> disease models of the central nervous system.

Yildirimer, L., Zhang, Q., Kuang, S., Cheung, C.-W.James, Chu, K.Alexander, He, Y., Yang, M., and Zhao, X. (2019). Engineering three-dimensional microenvironments towards in vitro disease models of the central nervous system.Biofabrication.

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.

Connor-Robson, N., Booth, H., Martin, J.G., Gao, B., Li, K., Doig, N., Vowles, J., Browne, C., Klinger, L., Juhasz, P., et al. (2019). An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.Neurobiol Dis.

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.

Redmond, S.A., Figueres-Oñate, M., Obernier, K., Nascimento, M.Assis, Parraguez, J.I., López-Mascaraque, L., Fuentealba, L.C., and Alvarez-Buylla, A. (2019). Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.Cell Rep27, 429-441.e3.

A 17 gene panel for non-small cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition.

Chen, Y.-L., Zhang, Y., Wang, J., Chen, N., Fang, W., Zhong, J., Liu, Y., Qin, R., Yu, X., Sun, Z., et al. (2019). A 17 gene panel for non-small cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition.Mol Oncol.

Adipose-derived stromal vascular fraction and cultured stromal cells as trophic mediators for tendon healing.

Polly, S.S., Nichols, A.Ec, Donnini, E., Inman, D.J., Scott, T.J., Apple, S.M., Werre, S.R., and Dahlgren, L.A. (2019). Adipose-derived stromal vascular fraction and cultured stromal cells as trophic mediators for tendon healing.J Orthop Res.

FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells.

Audesse, A.J., Dhakal, S., Hassell, L.-A., Gardell, Z., Nemtsova, Y., and Webb, A.E. (2019). FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells.Plos Genet15, e1008097.

Fabrication of gold-silver core-shell nanoparticles for performing as ultrabright SERS-nanotags inside human ovarian cancer cells.

Hada, A.Milentie, Potara, M., Suarasan, S., Vulpoi, A., Nagy-Simon, T., Licarete, E., and Astilean, S. (2019). Fabrication of gold-silver core-shell nanoparticles for performing as ultrabright SERS-nanotags inside human ovarian cancer cells.Nanotechnology.

Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.

Sinha, K.M., Tseng, C., Guo, P., Lu, A., Pan, H., Gao, X., Andrews, R., Eltzschig, H., and Huard, J. (2019). Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice.Faseb Jfj201801794R.

Patient-Reported Outcome Results From the Open-Label, Randomized Phase III Myeloma X Trial Evaluating Salvage Autologous Stem-Cell Transplantation in Relapsed Multiple Myeloma.

Ahmedzai, S.H., Snowden, J.A., Ashcroft, A.John, Cairns, D.Allan, Williams, C., Hockaday, A., Cavenagh, J.D., Ademokun, D., Tholouli, E., Allotey, D., et al. (2019). Patient-Reported Outcome Results From the Open-Label, Randomized Phase III Myeloma X Trial Evaluating Salvage Autologous Stem-Cell Transplantation in Relapsed Multiple Myeloma.J Clin OncolJCO1801006.

TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

Ng-Blichfeldt, J.-P., de Jong, T., Kortekaas, R.K., Wu, X., Lindner, M., Guryev, V., Hiemstra, P.S., Stolk, J., Koenigshoff, M., and Gosens, R. (2019). TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.Am J Physiol Lung Cell Mol Physiol.

Bone marrow mesenchymal stem cells-derived conditioned medium protects cardiomyocytes from hypoxia/reoxygenation-induced injury through Notch2/mTOR/autophagy signaling.

Li, X., Xie, X., Yu, Z., Chen, Y., Qu, G., Yu, H., Luo, B., Lei, Y., and Li, Y. (2019). Bone marrow mesenchymal stem cells-derived conditioned medium protects cardiomyocytes from hypoxia/reoxygenation-induced injury through Notch2/mTOR/autophagy signaling.J Cell Physiol.

Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease.

Moghaddam, A.Shapouri, Afshari, J.Tavakol, Esmaeili, S.-A., Saburi, E., Joneidi, Z., and Momtazi-Borojeni, A.Abbas (2019). Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease.Atherosclerosis285, 1-9.

Downregulation of microRNA-214 improves therapeutic potential of allogeneic bone marrow-derived mesenchymal stem cell by targeting PIM-1 in rats with acute liver failure.

Yang, J., Li, R., Zhao, D., and Zheng, S. (2019). Downregulation of microRNA-214 improves therapeutic potential of allogeneic bone marrow-derived mesenchymal stem cell by targeting PIM-1 in rats with acute liver failure.J Cell Biochem.

The inflammatory cytokine TNF-α regulates the biological behavior of rat nucleus pulposus mesenchymal stem cells through the NF-κB signaling pathway in vitro.

Cheng, S., Li, X., Jia, Z., Lin, L., Ying, J., Wen, T., Zhao, Y., Guo, Z., Zhao, X., Li, D., et al. (2019). The inflammatory cytokine TNF-α regulates the biological behavior of rat nucleus pulposus mesenchymal stem cells through the NF-κB signaling pathway in vitro.J Cell Biochem.

Isolation, Propagation, and Prion Protein Expression During Neuronal Differentiation of Human Dental Pulp Stem Cells.

Martellucci, S., Santacroce, C., Manganelli, V., Santilli, F., Piccoli, L., Cassetta, M., Misasi, R., Sorice, M., and Mattei, V. (2019). Isolation, Propagation, and Prion Protein Expression During Neuronal Differentiation of Human Dental Pulp Stem Cells.J Vis Exp.

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells.

Makabe, K., Sugita, S., Hono, A., Kamao, H., and Takahashi, M. (2019). Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells.Invest Ophthalmol Vis Sci60, 1298-1308.

An induced pluripotent stem cell line (TRNDi006-A) from a MPS IIIB patient carrying homozygous mutation of p.Glu153Lys in the NAGLU gene.

Huang, W., Xu, M., Li, R., Baskfield, A., Kouznetsova, J., Beers, J., Zou, J., Liu, C., and Zheng, W. (2019). An induced pluripotent stem cell line (TRNDi006-A) from a MPS IIIB patient carrying homozygous mutation of p.Glu153Lys in the NAGLU gene.Stem Cell Res37, 101427.

3D bioprinted hydrogel model incorporating β-tricalcium phosphate for calcified cartilage tissue engineering.

Kosik-Kozioł, A., Costantini, M., Mróz, A., Idaszek, J., Heljak, M., Jaroszewicz, J., Kijeńska, E., Szoke, K., Frerker, N., Barbetta, A., et al. (2019). 3D bioprinted hydrogel model incorporating β-tricalcium phosphate for calcified cartilage tissue engineering.Biofabrication.

The cyanobacterial neurotoxin β-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells.

Cheng, F., Fransson, L.-Å., and Mani, K. (2019). The cyanobacterial neurotoxin β-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells.Exp Cell Res.

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques.

Mooranian, A., Zamani, N., Takechi, R., Luna, G., Mikov, M., Goločorbin-Kon, S., Elnashar, M., Arfuso, F., and Al-Salami, H. (2019). An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques.Plos One14, e0214984.

An engineered mouse embryonic stem cell model with survivin as a molecular marker and EGFP as the reporter for high throughput screening of embryotoxic chemicals in vitro.

Zang, R., Xin, X., Zhang, F., Li, D., and Yang, S.-T. (2019). An engineered mouse embryonic stem cell model with survivin as a molecular marker and EGFP as the reporter for high throughput screening of embryotoxic chemicals in vitro.Biotechnol Bioeng.