Papers of the Week

February 11 - February 17, 2019

JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation.

Kong, X., Gong, Z., Zhang, L., Sun, X., Ou, Z., Xu, B., Huang, J., Long, D., He, X., Lin, X., et al. (2019). JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation.Brain Behav Immun.

Transcription factor USF1 is required for maintenance of germline stem cells in male mice.

Faisal, I., Cisneros-Montalvo, S., Hamer, G., Tuominen, M., Laurila, P.-P., Tumiati, M., Jauhiainen, M., Kotaja, N., Toppari, J., Mäkelä, J.-A., et al. (2019). Transcription factor USF1 is required for maintenance of germline stem cells in male mice.Endocrinology.

Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons.

Deneault, E., White, S.H., Rodrigues, D.C., P Ross, J., Faheem, M., Zaslavsky, K., Wang, Z., Alexandrova, R., Pellecchia, G., Wei, W., et al. (2019). Complete Disruption of Autism-Susceptibility Genes by Gene Editing Predominantly Reduces Functional Connectivity of Isogenic Human Neurons.Stem Cell Reports12, 427-429.

Co-culture with monocytes/macrophages modulates osteogenic differentiation of adipose-derived mesenchymal stromal cells on PLGA/PCL scaffolds.

Tang, H., Husch, J.F.A., Zhang, Y., Jansen, J.A., Yang, F., and van den Beucken, J.J.J.P. (2019). Co-culture with monocytes/macrophages modulates osteogenic differentiation of adipose-derived mesenchymal stromal cells on PLGA/PCL scaffolds.J Tissue Eng Regen Med.

Natural and synthetic nanopores directing osteogenic differentiation of human stem cells.

Greiner, J.Fw, Gottschalk, M., Fokin, N., Büker, B., Kaltschmidt, B.Peter, Dreyer, A., Vordemvenne, T., Kaltschmidt, C., Hütten, A., and Kaltschmidt, B. (2019). Natural and synthetic nanopores directing osteogenic differentiation of human stem cells.Nanomedicine.

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions.

Gandhi, J.K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K.N., Metko, M.M., Ackerman, M.J., Resch, Z., et al. (2019). Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions.Stem Cells Transl Med.

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.

Minata, M., Audia, A., Shi, J., Lu, S., Bernstock, J., Pavlyukov, M.S., Das, A., Kim, S.-H., Shin, Y.Jae, Lee, Y., et al. (2019). Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation.Cell Rep26, 1893-1905.e7.

Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf-Induced Tumorigenesis.

Tao, Y., Kang, B., Petkovich, D.A., Bhandari, Y.R., In, J., Stein-O'Brien, G., Kong, X., Xie, W., Zachos, N., Maegawa, S., et al. (2019). Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and Braf-Induced Tumorigenesis.Cancer Cell35, 315-328.e6.

Hematopoietic Stem Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.

McNeer, J.L., Devidas, M., Dai, Y., Carroll, A.J., Heerema, N.A., Gastier-Foster, J.M., Kahwash, S.B., Borowitz, M.J., Wood, B.L., Larsen, E., et al. (2019). Hematopoietic Stem Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group.J Clin OncolJCO1800884.

Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants.

Stadnikova, A., Trosan, P., Skalicka, P., Utheim, T.Paaske, and Jirsova, K. (2019). Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants.Plos One14, e0211861.

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.

Neelakantan, H., Brightwell, C.R., Graber, T.Gfoch, Maroto, R., Wang, H.-Y.Leo, McHardy, S.F., Papaconstantinou, J., Fry, C.S., and Watowich, S.J. (2019). Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.Biochem Pharmacol.

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon, F., Cherubini, M., Fernandes, H.J.R., Lang, C., Ryan, B.J., Volpato, V., Bengoa-Vergniory, N., Vingill, iv, S., Attar, M., Booth, H.D.E., et al. (2019). Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.Hum Mol Genet.

CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.

Jung, J., Buisman, S.C., Weersing, E., Dethmers-Ausema, A., Zwart, E., Schepers, H., Dekker, M.R., Lazare, S.S., Hammerl, F., Skokova, Y., et al. (2019). CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.Cell Rep26, 1906-1918.e8.

Mesenchymal Stromal Cell-Derived Exosomes Attenuate Myocardial Ischemia-Reperfusion Injury through miR-182-Regulated Macrophage Polarization.

Zhao, J., Li, X., Hu, J., Chen, F., Qiao, S., Sun, X., Gao, L., Xie, J., and Xu, B. (2019). Mesenchymal Stromal Cell-Derived Exosomes Attenuate Myocardial Ischemia-Reperfusion Injury through miR-182-Regulated Macrophage Polarization.Cardiovasc Res.

From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2.

Schwartz, P.J., Gnecchi, M., Dagradi, F., Castelletti, S., Parati, G., Spazzolini, C., Sala, L., and Crotti, L. (2019). From patient-specific induced pluripotent stem cells to clinical translation in long QT syndrome Type 2.Eur Heart J.

A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.

Glantschnig, C., Koenen, M., Lozano, M.Gil, Karbiener, M., Pickrahn, I., Williams-Dautovich, J., Patel, R., Cummins, C.L., Giroud, M., Hartleben, G., et al. (2019). A miR-29a-driven negative feedback loop regulates peripheral glucocorticoid receptor signaling.Faseb Jfj201801385RR.