Papers of the Week

October 22 - October 28, 2018

Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain.

Anderson, N.C., Van Zandt, M.A., Shrestha, S., Lawrence, D.B., Gupta, J., Chen, C.Y., Harrsch, F.A., Boyi, T., Dundes, C.E., Aaron, G., et al. (2018). Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain.Stem Cell Res33, 83-94.

Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells.

Nargesi, A.Aghajani, Zhu, X.-Y., Hickson, L.T.J., Conley, S.M., van Wijnen, A.J., Lerman, L.O., and Eirin, A. (2018). Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells.Stem Cell Rev.

Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.

Nazir, F.Hayat, Becker, B., Brinkmalm, A., Höglund, K., Sandelius, Å., Bergström, P., Satir, T.Munise, Öhrfelt, A., Blennow, K., Agholme, L., et al. (2018). Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.Neurochem Int.

Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 Expression.

Kim, S.-H., Jung, J., Cho, K.Jin, Choi, J.-H., Lee, H.Seon, Kim, G.Jin, and Lee, S.Gwan (2018). Immunomodulatory Effects of Placenta-derived Mesenchymal Stem Cells on T Cells by Regulation of FoxP3 Expression.Int J Stem Cells.

Pancreatic endocrine-like cells differentiated from human umbilical cords Wharton's jelly mesenchymal stem cells using small molecules.

Shivakumar, S.Belame, Bharti, D., Subbarao, R.Baregundi, Park, J.-M., Son, Y.-B., Ullah, I., Choe, Y.-H., Lee, H.-J., Park, B.-W., Lee, S.-L., et al. (2018). Pancreatic endocrine-like cells differentiated from human umbilical cords Wharton's jelly mesenchymal stem cells using small molecules.J Cell Physiol.

Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury.

Obara, K., Tohgi, N., Shirai, K., Mii, S., Hamada, Y., Arakawa, N., Aki, R., Singh, S.Ram, Hoffman, R.M., and Amoh, Y. (2018). Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Encapsulated on Polyvinylidene Fluoride Membranes (PFM) Promote Functional Recovery from Spinal Cord Injury.Stem Cell Rev.

Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling.

Zhang, C., Lee, H.Joo, Shrivastava, A., Wang, R., McQuiston, T.J., Challberg, S.S., Pollok, B.A., and Wang, T. (2018). Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling.Cell Rep25, 598-610.e5.

Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.

Karagiannis, P., Takahashi, K., Saito, M., Yoshida, Y., Okita, K., Watanabe, A., Inoue, H., Yamashita, J.K., Todani, M., Nakagawa, M., et al. (2019). Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.Physiol Rev99, 79-114.

Loss of EfnB1 in the osteogenic lineage compromises their capacity to support haematopoietic stem/ progenitor cell maintenance.

Arthur, A., Nguyen, T.M., Paton, S., Zannettino, A.C.W., and Gronthos, S. (2018). Loss of EfnB1 in the osteogenic lineage compromises their capacity to support haematopoietic stem/ progenitor cell maintenance.Exp Hematol.

Inhibition of miR-449a Promotes Cartilage Regeneration and Prevents Progression of Osteoarthritis in In Vivo Rat Models.

Baek, D., Lee, K.-M., Park, K.Won, Suh, J.Wan, Choi, S.Mi, Park, K.Hwan, Lee, J.Woo, and Kim, S.-H. (2018). Inhibition of miR-449a Promotes Cartilage Regeneration and Prevents Progression of Osteoarthritis in In Vivo Rat Models.Mol Ther Nucleic Acids13, 322-333.

Knockdown of lncRNA KCNQ1OT1 suppresses the adipogenic and osteogenic differentiation of tendon stem cell via downregulating miR-138 target genes PPARγand RUNX2.

Yu, Y., Chen, Y., Zhang, X., Lu, X., Hong, J., Guo, X., and Zhou, D. (2018). Knockdown of lncRNA KCNQ1OT1 suppresses the adipogenic and osteogenic differentiation of tendon stem cell via downregulating miR-138 target genes PPARγand RUNX2.Cell Cycle.

Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA carriers.

Ponandai-Srinivasan, S., Lalitkumar, P.G., Garcia, L., Varghese, S.Jo, Carlson, J.W., Gemzell-Danielsson, K., and Radestad, A.Floter (2018). Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA carriers.Acta Obstet Gynecol Scand.

OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.

Hrit, J., Goodrich, L., Li, C., Wang, B.-A., Nie, J., Cui, X., Martin, E.Allene, Simental, E., Fernandez, J., Liu, M.Y., et al. (2018). OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.Elife7.

Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.

Schick, R., Mekies, L.N., Shemer, Y., Eisen, B., Hallas, T., Ben Jehuda, R., Ben-Ari, M., Szantai, A., Willi, L., Shulman, R., et al. (2018). Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.Plos One13, e0205719.

Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.

Joost, S., Jacob, T., Sun, X., Annusver, K., La Manno, G., Sur, I., and Kasper, M. (2018). Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing.Cell Rep25, 585-597.e7.

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.

An, Y., Adams, J.R., Hollern, D.P., Zhao, A., Chang, S.G., Gams, M.S., Chung, P.E.D., He, X., Jangra, R., Shah, J.S., et al. (2018). Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast.Cell Rep25, 702-714.e6.

Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction.

Zafar, N., Krishnasamy, S.S., Shah, J., Rai, S.N., Riggs, D.W., Bhatnagar, A., and O'Toole, T.E. (2018). Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction.Plos One13, e0205851.