Stembook Sections:
Cellular and nuclear reprogramming »
  • Inducing pluripotency
  • Stem cells in animal models of regeneration
  • Small RNAs – their biogenesis, regulation and function in embryonic stem cells
Ectoderm specification and differentiation »
  • The cranial sensory nervous system: specification of sensory progenitors and placodes
  • Tooth organogenesis and regeneration
  • Melanocyte stem cells
Endoderm specification and differentiation »
  • Pancreatic stem cells
  • Specification and patterning of the respiratory system
  • Liver development
Epigenetics »
  • Epigenetic mechanisms controlling mesodermal specification
  • Imaging chromatin in embryonic stem cells
  • Epigenetic silencing during early lineage commitment
Genomics and proteomics »
  • Proteomic studies of stem cells
  • Genome-wide transcription factor localization and function in stem cells
  • The pluripotent transcriptome
Germ cell and somatic stem cell biology in reproduction »
  • Regulation of spermatogonia
  • piRNA function in germline development
  • The role of microRNAs in germline differentiation
Manufacturing »
  • Regulatory challenges for the manufacture and scale-out of autologous cell therapies
  • From production to patient: challenges and approaches for delivering cell therapies
Mesoderm specification and differentiation »
  • Epigenetic mechanisms controlling mesodermal specification
  • Mouse kidney development
  • Adult mesenchymal stem cells
Niche biology, homing, and migration »
  • Hematopoietic stem cell trafficking
  • The neural stem cell microenvironment
Renewal »
  • Aging and stem cell renewal
  • Quiescent stem cells in the niche
  • Mechanisms regulating stem cell polarity and the specification of asymmetric divisions
Stem cell immunology »
  • Immunologic targeting of the cancer stem cell
  • Immunological considerations for cell therapy using human embryonic stem cell derivatives
  • Mouse models of graft-versus-host disease
Therapeutic prospects »
  • The hematopoietic stem cell niche
  • Medical applications of epidermal stem cells
  • Mesenchymal stromal cells as a drug delivery system
Tissue engineering »
  • Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery
  • Autologous approaches to tissue engineering
  • Flow perfusion culture of mesenchymal stem cells for bone tissue engineering

News & Commentaries

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CWRU Scientists Develop New Method to More Efficiently Generate Brain Stem Cells

case western

Cleveland, OH, USA – In two newly published papers, a scientific team at Case Western Reserve University School of Medicine reports on the discovery and implementation of a new, more efficient method for generating an important brain stem cell in the laboratory. The findings pave the way for greater understanding of the underlying mechanisms of neurological disorders of myelin and ultimately, possible new treatment and prevention options. The studies were published in the September issues of Nature Communications and Stem Cell Reports.

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Immune Cells Help Older Muscles Heal Like New

duke university news

Durham, NC, USA – Biomedical engineers at Duke University have found a critical component for growing self-healing muscle tissues from adult muscle – the immune system. The discovery in mice is expected to play an important role in studying degenerative muscle diseases and enhancing the survival of engineered tissue grafts in future cell therapy applications. The results appeared online October 1 in Nature Biomedical Engineering.

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3D Bioprinting of Living Structures with Built-In Chemical Sensors

uni of copenhagen

Copenhagen, Denmark – A new method enables non-invasive monitoring of oxygen metabolism in cells that are 3D bioprinted into complex living structures. This has great implications for studies of cell growth and interactions e.g. under tissue-like conditions, as well as for the design of 3D printed constructs facilitating higher productivity of microalgae in biofilms or better oxygen supply for stem cells used in bone and tissue reconstruction efforts.