Stembook Sections:
Cellular and nuclear reprogramming »
  • Inducing pluripotency
  • Stem cells in animal models of regeneration
  • Small RNAs – their biogenesis, regulation and function in embryonic stem cells
Ectoderm specification and differentiation »
  • The cranial sensory nervous system: specification of sensory progenitors and placodes
  • Tooth organogenesis and regeneration
  • Melanocyte stem cells
Endoderm specification and differentiation »
  • Pancreatic stem cells
  • Specification and patterning of the respiratory system
  • Liver development
Epigenetics »
  • Epigenetic mechanisms controlling mesodermal specification
  • Imaging chromatin in embryonic stem cells
  • Epigenetic silencing during early lineage commitment
Genomics and proteomics »
  • Proteomic studies of stem cells
  • Genome-wide transcription factor localization and function in stem cells
  • The pluripotent transcriptome
Germ cell and somatic stem cell biology in reproduction »
  • Regulation of spermatogonia
  • piRNA function in germline development
  • The role of microRNAs in germline differentiation
Manufacturing »
  • Regulatory challenges for the manufacture and scale-out of autologous cell therapies
  • From production to patient: challenges and approaches for delivering cell therapies
Mesoderm specification and differentiation »
  • Epigenetic mechanisms controlling mesodermal specification
  • Mouse kidney development
  • Adult mesenchymal stem cells
Niche biology, homing, and migration »
  • Hematopoietic stem cell trafficking
  • The neural stem cell microenvironment
Renewal »
  • Aging and stem cell renewal
  • Quiescent stem cells in the niche
  • Mechanisms regulating stem cell polarity and the specification of asymmetric divisions
Stem cell immunology »
  • Immunologic targeting of the cancer stem cell
  • Immunological considerations for cell therapy using human embryonic stem cell derivatives
  • Mouse models of graft-versus-host disease
Therapeutic prospects »
  • The hematopoietic stem cell niche
  • Medical applications of epidermal stem cells
  • Mesenchymal stromal cells as a drug delivery system
Tissue engineering »
  • Molecular Imaging of Stem Cells **NEW**
  • Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery **NEW**
  • Autologous approaches to tissue engineering

News & Commentaries

UMD Researchers Perform Crucial Proof-of-Concept Experiment, Paving the Way for Growing Human Organs for Therapeutics and Transplantation

Stembook: UMD Researchers Perform Crucial Proof-of-Concept Experiment, Paving the Way for Growing Human Organs for Therapeutics and Transplantation
Start-up company, Renovate Bioscience Inc., wins Invention of the Year and Inventor Pitch Award for this work at UMD

College Park, MD, USA – In a new paper published in Stem Cell Reports, Bhanu Telugu and co-inventor Chi-Hun Park of the University of Maryland (UMD) Department of Animal and Avian Sciences show for the first time that newly established stem cells from pigs, when injected into embryos, contributed to the development of only the organ of interest (the embryonic gut and liver), laying the groundwork for stem cell therapeutics and organ transplantation.

Oh So Simple: Eight Genes Enough to Convert Mouse Stem Cells into Oocyte-Like Cells

Stembook: Oh So Simple: Eight Genes Enough to Convert Mouse Stem Cells into Oocyte-Like Cells
Surprisingly simple method could provide a new tool for producing specialized cytoplasm for reproductive medicine.

Fukuoka, Japan – In a new study published in the journal Nature, researchers in Japan report that activating just eight genes for producing gene-controlling proteins is enough to convert mouse stem cells directly into oocyte-like cells that mature and can even be fertilized like egg cells.