Random versus deterministic input into stem cell lineage choice
"Everything ... depends on these and only on these: A set of fixed, deterministic laws. A purely random set of accidents." -- Marvin Minsky
News & Commentaries
Stem cell maintenance factors represent potential therapeutic targets for cancer
Cancer stem cells are capable of initiating and sustaining a tumor. Current cancer therapies may fail, leaving patients prone to recurrence because the cancer stem cells have not been eradicated.
Genomic approaches provide insights into the molecular basis of pluripotency
Nuclear reprogramming demonstrates the potential for reversability in cellular differentiation.