News & Commentaries

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UMN Medical School Researchers Explain Muscle Loss with Menopause

STEMBOOK: UMN Medical School Researchers Explain Muscle Loss with Menopause

Minneapolis, MN, USA – New University of Minnesota Medical School research is the first to show that estrogen is essential to maintaining muscle stem cell health. In an article recently published in Cell Reports, lead authors Dawn Lowe and Carrie Ramey/CCRF are the first to establish that estrogen is essential in females for muscle stem cell maintenance and function.

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Making Cancer Stem Cells Visible to the Immune System – New Results May Enable Innovative Treatment Concept Against Leukemia

[STEMBOOK]: Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia

Heidelberg, Germany – Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal Nature, scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results. A joint press release of the German Cancer Research Center (DKFZ), the German Cancer Consortium (DKTK), and the University Hospital Tübingen.

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Re­pair of Aged Tis­sue Can be En­hanced by in­hib­it­ing Sig­nals from Neigh­bor­ing Cells

[STEMBOOK] Re­pair of aged tis­sue can be en­hanced by in­hib­it­ing sig­nals from neigh­bour­ing cells

Helsinki, Finland – Researchers at the University of Helsinki have discovered how regenerative capacity of intestinal epithelium declines when we age. Targeting of an enzyme that inhibits stem cell maintaining signaling rejuvenates the regenerative potential of an aged intestine. This finding may open ways to alleviate age-related gastrointestinal problems, reduce side-effects of cancer treatments, and reduce healthcare costs in the ageing society by promoting recovery. The article was published in Nature.

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Megakaryocytes Act As „Bouncers“ Restraining Cell Migration in the Bone Marrow

STEMBOOK: Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow

Würzburg, Germany – Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal Haematologica.

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Slug, A Stem Cell Regulator, Keeps Breast Cells Healthy by Promoting Repair of DNA Damage

STEMBOOK: Slug, a stem cell regulator, keeps breast cells healthy by promoting repair of DNA damage

Boston, MA, USA – A new study published in Cell Reports found that a transcription factor called Slug serves as ‘command central’ for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage. The research team also discovered that Slug likely functions as a safeguard against age-related decline of breast stem cell function.

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World First: Homing Instinct Applied to Stem Cells Show Cells "Home" to Cardiac Tissue

[STEMBOOK] World first: Homing instinct applied to stem cells show cells 'home' to cardiac tissue
Scientists hijack bacteria's homing ability

Bristol, UK – In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK (1). To date, trials using stem cells, which are taken and grown from the patient or donor and injected into the patient's heart to regenerate damaged tissue, have produced promising results.

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Scientists Developing Way to Help Premature Babies Breathe Easier

StemBook: Scientists developing way to help premature babies breathe easier (stem cells)
Study points to possible cell therapy for bronchopulmonary dysplasia

Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death.

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