News & Commentaries

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NIH-supported Study Reveals a Novel Indicator of Influenza Immunity

StemBook: NIH-supported Study Reveals a Novel Indicator of Influenza Immunity(stem cells)

Bethesda, MD, USA – A study of influenza virus transmission in Nicaraguan households reveals new insights into the type of immune responses that may be protective against influenza virus infection, report investigators. The findings could help scientists design more effective influenza vaccines and lead to the development of novel universal influenza vaccines. The research was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

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Major Stem Cell Discovery To Boost Research Into Development And Regenerative Medicine

Expanded Potential Stem Cell lines of pig and human cells established

Cambridgeshire, UK — A new approach has enabled researchers to create Expanded Potential Stem Cells (EPSCs) of both pig and human cells. These stem cells have the features of the very first cells in the developing embryo, and can develop into any type of cell. The research from LKS Faculty of Medicine of The University of Hong Kong (HKUMed), the Wellcome Sanger Institute, and the Friedrich-Loeffler-Institut in Germany offers incredible potential for studying human development and regenerative medicine.

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New Genetic Weapons Challenge Sickle Cell Disease

StemBook: New Genetic Weapons Challenge Sickle Cell Disease (stem cells)
Rice lab’s CRISPR-Cas9 strategy offers two-pronged attack

Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient’s own protective fetal hemoglobin.New research shows that using CRISPR-Cas9 and a corrective short DNA template to repair the sickle cell mutation in a patient’s hematopoietic stem cells (HSCs) could be efficient and safe.

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Stem Cells Delivered to the Nose Restore Mice’s Ability to Smell

StemBook: Stem Cells Delivered to the Nose Restore Mice’s Ability to Smell (stem cells)
The introduced cells engrafted in the nose, became olfactory sensory neurons, and sent axons to the animals’ brains

In mice whose sense of smell has been disabled, a squirt of stem cells into the nose can restore olfaction, researchers report today (May 30) in Stem Cell Reports. The introduced “globose basal cells,” which are precursors to smell-sensing neurons, engrafted in the nose, matured into nerve cells, and sent axons to the mice’s olfactory bulbs in the brain.

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Scientists Develop Gel-based Delivery System for Stem Cell-derived Factors to Improve Kidney Regeneration

In ongoing research to find a treatment for acute kidney injury, Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have further advanced a promising approach using therapeutic factors produced by stem cells by creating a more efficient delivery method that would improve tissue regeneration. WFIRM researchers wanted to determine if any of the growth factors could lead to kidney function recovery. They developed a gel-based system that contained a cocktail of stem cell derived growth factors.

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Stem Cell Study Determines Most Harmful Vape Liquids

Stembook: Stem Cell Study Determines Most Harmful Vape Liquids
Are some flavors of vape liquid more harmful than others? A UA scientist says yes, based on the results of a novel research project that used stem cells to study the effects of vaping on endothelial cells

Phoenix, AZ, USA — Your favorite vape flavor may be more harmful than the nicotine itself. Using stem cells to investigate the impact of e-liquids on cardiovascular disease, a new study has revealed the harmful effects of flavored e-cigarette liquids and e-cigarette use.

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Cancer Cells Are Quick-change Artists Adapting to Their Environment

STEMBOOK: Cancer cells are quick-change artists adapting to their environment
Inherent cancer stem cell plasticity uncovered

Esch-sur-Alzette, Luxembourg — Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order. Accordingly, such cancer stem cells are responsible for tumor progression and produce specific types of more differentiated cancer cells whose fates are predetermined. In a joint interdisciplinary project led by the Luxembourg Institute of Health (LIH), researchers now show that cancer cells of glioblastomas - conspicuously aggressive solid brain tumors - manifest developmental plasticity and their phenotypic characteristics are less constrained than believed. Cancer stem cells, including their progeny, are able to adapt to environmental conditions and undergo reversible transformations into various cell types, thereby altering their surface structures. The results imply that novel therapeutic approaches, which target specific surface structures of cancer stem cells, will be of limited utility. The research team has published its findings in Nature Communications in April 2019.

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Study Reveals Factors Behind Embryonic Stem Cell State

ACS news

Washington, DC, USA – What if doctors had a remote control that they could use to steer a patient’s own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal Nano Letters have taken an important first step: They used near-infrared light and an injected DNA nanodevice to guide stem cells to an injury, which helped muscle tissue regrow in mice.

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Surprising Research Result: All Immature Cells Can Develop into Stem Cells

Copenhagen, Denmark – New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The new knowledge may make it easier to manipulate stem cells for stem cell therapy. The results have just been published in Nature.

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