Research led by scientists at Harvard and the Broad Institute has optimized the process of making human brain ‘organoids’ – miniature 3D organ models – so they consistently follow growth patterns observed in the developing human brain.
Researchers can use this reproducible experimental system to test drugs for neuropsychiatric diseases like autism spectrum disorder and schizophrenia directly in human tissues.
Bethesda, MD, USA – A study of influenza virus transmission in Nicaraguan households reveals new insights into the type of immune responses that may be protective against influenza virus infection, report investigators.
Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient’s own protective fetal hemoglobin.New research shows that using CRISPR-Cas9 and a corrective short DNA template to repair the sickle cell mutation in a patient’s hematopoietic stem cells (HSCs) could be efficient and safe.
Washington, DC, USA – What if doctors had a remote control that they could use to steer a patient’s own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal Nano Letters have taken an important first step: They used near-infrared light and an injected DNA nanodevice to guide stem cells to an injury, which helped muscle tissue regrow in mice.
Copenhagen, Denmark – New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells' surroundings. The new knowledge may make it easier to manipulate stem cells for stem cell therapy. The results have just been published in Nature.
Kobe, Japan – Our hair, skin and eyes are colored by a pigment called melanin, which is produced by pigment cells called melanocytes. Scientists have used stem cell technology to successfully create melanocyte precursor cells. These cells can be used in research on melanoma and other pigment cell-related illnesses. The findings were published on March 6 in the online edition of Pigment Cell & Melanoma Research.
Amsterdam, NL – StemJournal, a new open access, peer-reviewed journal published by IOS Press, announces publication of its inaugural article, "Combining Stem Cells and Biomaterial Scaffolds for Constructing Tissues and Cell Delivery" by Stephanie M. Willerth, PhD, and Shelly E. Sakiyama-Elbert, PhD. This timely overview of the available biomaterials for directing stem cell differentiation as a means of producing replacements for diseased or damaged tissues is a comprehensive update of the classic review published in StemBook in 2008.
Monash, Australia – Embryonic stem cells (ESC) have the ability to self-renew, and, being pluripotent have the potential to create almost any cell type in the body. The embryonic stem cell state is established and maintained by multiple regulatory networks that include epigenetic regulators; the function of these epigenetic regulators though has not been well-defined.
La Jolla, CA, USA – Lying within our muscles are stem cells, invisible engines that drive the tissue’s growth and repair. Understanding the signal(s) that direct muscle stem cells to spring into action could uncover new ways to promote muscle growth. However, these mechanisms are poorly understood.
Toronto, Canada – Glioblastoma is one of the most devastating forms of cancer, with few existing treatment options. It is also a leading cause of cancer-related death in children and young adults. Scientists have "reverse engineered" brain cancer stem cells gene by gene, uncovering multiple potential targets for this hard-to-treat cancer.
