Biblio

Author Title Type [ Year(Asc)]
Filters: Author is Lai, Liangxue  [Clear All Filters]
2024
Li X-J, Lai L. A booming field of large animal model research. Zool Res. 2024;45(2):311-313.
Han Y, Zhou J, Zhang R, Liang Y, Lai L, Li Z. Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases. Zool Res. 2024;45(2):253-262.
Xu J, Guo P, Hao S, Shangguan S, Shi Q, Volpe G, Huang K, Zuo J, An J, Yuan Y, et al. A spatiotemporal atlas of mouse liver homeostasis and regeneration. Nat Genet. 2024.
Liang M, Zhang L, Lai L, Li Z. Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A. Cell Mol Life Sci. 2024;81(1):156.
2023
Liang Y, Chen F, Wang K, Lai L. Base editors: development and applications in biomedicine. Front Med. 2023.
Liao R, Wu Y, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, et al. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO J. 2023:e113448.
Yan S, Zheng X, Lin Y, Li C, Liu Z, Li J, Tu Z, Zhao Y, Huang C, Chen Y, et al. Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease. Nat Biomed Eng. 2023.
Qian Y, Wang D, Niu W, Shi Z, Wu M, Zhao D, Li J, Gao X, Zhang Z, Lai L, et al. Development of a highly efficient prime editor system in mice and rabbits. Cell Mol Life Sci. 2023;80(11):346.
Jin Q, Liu X, Zhuang Z, Huang J, Gou S, Shi H, Zhao Y, Ouyang Z, Liu Z, Li L, et al. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation. Genome Biol. 2023;24(1):8.
Zhao D, Gao X, Zhou J, Li J, Qian Y, Wang D, Niu W, Zhang T, Hu M, Xiong H, et al. Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope. BMC Biol. 2023;21(1):250.
Luo X, Yang K, Jiang M, Chen T, Chi Y, Ma B, Lai L, Zou Q. Generation of a homozygous GRIN2A gene knockout human embryonic stem cell line using CRISPR/Cas9 system. Stem Cell Res. 2023;69:103121.
Lan T, Chen H, Tang C, Wei Y, Liu Y, Zhou J, Zhuang Z, Zhang Q, Chen M, Zhou X, et al. Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase. Mol Ther Nucleic Acids. 2023;33:890-897.
Tian R, Li Y, Zhao H, Lyu W, Zhao J, Wang X, Lu H, Xu H, Ren W, Tan Q-Q, et al. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. Mol Psychiatry. 2023.
Qian Y, Wang D, Niu W, Zhao D, Li J, Liu Z, Gao X, Han Y, Lai L, Li Z. A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9. BMC Biol. 2023;21(1):155.
Xie J, Zhuang Z, Gou S, Zhang Q, Wang X, Lan T, Lian M, Li N, Liang Y, Ouyang Z, et al. Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription. Nucleic Acids Res. 2023.
Chen T, Tang C, Zheng W, Qian Y, Chen M, Zou Q, Jin Y, Wang K, Zhou X, Gou S, et al. VCFshiny: an R/Shiny application for interactively analyzing and visualizing genetic variants. Bioinform Adv. 2023;3(1):vbad107.
2022
Jin Q, Yang X, Gou S, Liu X, Zhuang Z, Liang Y, Shi H, Huang J, Wu H, Zhao Y, et al. Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. Sci China Life Sci. 2022.
Chen S, Liu Z, Yu H, Lai L, Li Z. Efficient multi-nucleotide deletions using deaminase-Cas9 fusions in human cells. J Genet Genomics. 2022.
Zhu Y, Zhang Z, Fan N, Huang K, Li H, Gu J, Zhang Q, Ouyang Z, Zhang T, Tang J, et al. Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells. Stem Cell Reports. 2022.
Jia Y, Wang T, Zhao D, Liu Z, Sui T, Chen S, Li J, Lai L, Li Z. Targeted mutagenesis in rabbit using an engineered BhCas12b variant. J Mol Cell Biol. 2022.
Liu Z, Chen S, Xie W, Yu H, Lai L, Li Z. Versatile and efficient genome editing with Neisseria cinerea Cas9. Commun Biol. 2022;5(1):1296.
2021
Yang Y, Kang X, Hu S, Chen B, Xie Y, Song B, Zhang Q, Wu H, Ou Z, Xian Y, et al. CRISPR/Cas9 mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia. J Biol Chem. 2021:100464.
2020
Chen S, Xie W, Liu Z, Shan H, Chen M, Song Y, Yu H, Lai L, Li Z. CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations. Mol Ther Nucleic Acids. 2020;21:1062-1073.
2019
Liu T, Wang J, Xie X, Wang K, Sui T, Liu D, Lai L, Zhao H, Li Z, Feng JQ. DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture. J Bone Miner Res. 2019.
Xie J, Ge W, Li N, Liu Q, Chen F, Yang X, Huang X, Ouyang Z, Zhang Q, Zhao Y, et al. Efficient base editing for multiple genes and loci in pigs using base editors. Nat Commun. 2019;10(1):2852.

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