Biblio

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2024
Loerch C, Szepanowski L-P, Reiss J, Adjaye J, Graffmann N. Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells. Front Cell Dev Biol. 2024;12:1383928.
2023
Royer-Pokora B, Wruck W, Adjaye J, Beier M. Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin. PLoS One. 2023;18(1):e0270380.
Nguyen L, Thewes L, Westerhoff M, Wruck W, Reichert AS, Berndt C, Adjaye J. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Cells. 2023;12(17).
2022
Erichsen L, Adjaye J. Crosstalk between age accumulated DNA-damage and the SIRT1-AKT-GSK3ß axis in urine derived renal progenitor cells. Aging (Albany NY). 2022;14(undefined).
Graffmann N, Scherer B, Adjaye J. In vitro differentiation of pluripotent stem cells into hepatocyte like cells - Basic principles and current progress. Stem Cell Res. 2022;61:102763.
2021
Graffmann N, Martins S, Ljubikj T, Matte JCarole, Bohndorf M, Wruck W, Adjaye J. Generation of a Crigler-Najjar Syndrome Type I patient-derived induced pluripotent stem cell line CNS705 (HHUUKDi005-A). Stem Cell Res. 2021;51:102167.
2020
Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, et al. Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res. 2020;45:101761.
2019
Dabiri Y, Gama-Brambila RA, Taškova K, Herold K, Reuter S, Adjaye J, Utikal J, Mrowka R, Wang J, Andrade-Navarro MA, et al. Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs. iScience. 2019;12:168-181.
Devika AS, Wruck W, Adjaye J, Sudheer S. The quest for pluripotency: a comparative analysis across mammalian species. Reproduction. 2019.
2018
Graffmann N, Ncube A, Wruck W, Adjaye J. Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density. PLoS One. 2018;13(7):e0200416.
Graffmann N, Bohndorf M, Ncube A, Kawala M-A, Wruck W, Kashofer K, Zatloukal K, Adjaye J. Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype. Stem Cell Res. 2018;31:113-116.
Graffmann N, Bohndorf M, Ncube A, Wruck W, Kashofer K, Zatloukal K, Adjaye J. Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype. Stem Cell Res. 2018;31:131-134.
Martins S, Bohndorf M, Graffmann N, Wruck W, Chrzanowska KH, Adjaye J. Fibroblast-derived integration-free iPSC line ISRM-NBS1 from an 18-year-old Nijmegen Breakage Syndrome patient carrying the homozygous NBN c.657_661del5 mutation. Stem Cell Res. 2018;34:101372.
Martins S, Yigit H, Bohndorf M, Graffmann N, Fiszl ARobert, Wruck W, Sleegers K, Van Broeckhoven C, Adjaye J. Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Stem Cell Res. 2018;30:141-144.
Spitzhorn L-S, Kordes C, Megges M, Sawitza I, Götze S, Reichert D, Schulze-Matz P, Graffmann N, Bohndorf M, Wruck W, et al. Transplanted human pluripotent stem cell-derived mesenchymal stem cells support liver regeneration in Gunn rats. Stem Cells Dev. 2018.
2016
Wruck W, Schröter F, Adjaye J. Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsiesand iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Revealsan Association with FOXA1 and FOXA2 Gene Regulatory Networks. J Alzheimers Dis. 2016.
Graffmann N, Ring S, Kawala M-A, Wruck W, Ncube A, Trompeter H-I, Adjaye J. Modelling NAFLD with human pluripotent stem cell derived immature hepatocyte like cells reveals activation of PLIN2 and confirms regulatory functions of PPARα. Stem Cells Dev. 2016.
2015
Graffmann N, Brands J, Görgens A, Castro SVitoriano, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JChristian, Adjaye J, et al. Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3. Stem Cells Dev. 2015.
Hossini AM, Megges M, Prigione A, Lichtner B, Toliat MR, Wruck W, Schröter F, Nuernberg P, Kroll H, Makrantonaki E, et al. Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks. BMC Genomics. 2015;16(1):433.
Cheng X, Dimou E, Alborzinia H, Wenke F, Goehring A, Reuter S, Mah N, Fuchs HRalph, Andrade-Navarro MA, Adjaye J, et al. Identification of 2-[4-[(4-methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers. J Med Chem. 2015.
2014
Fuchs H, Theuser M, Wruck W, Adjaye J. miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells. PLoS One. 2014;9(11):e111637.
Prigione A, Adjaye J. A mitochondrial strategy for safeguarding the reprogrammed genome. Cell Regen (Lond). 2014;3(1):5.
Schröter F, Adjaye J. The proteasome complex and the maintenance of pluripotency: sustain the fate by mopping up?. Stem Cell Res Ther. 2014;5(1):24.
2013
Peterson H, Dawud RAbu, Garg A, Wang Y, Vilo J, Xenarios I, Adjaye J. Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells. Front Physiol. 2013;4:303.