April 4 - April 10, 2022

Lose the Stress: Viscoelastic Materials for Cell Engineering.

Carvalho EM, Kumar S. Lose the Stress: Viscoelastic Materials for Cell Engineering. Acta Biomater. 2022.

EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients.

Mederer T, Elsner F, Robold T, Großer C, Neu R, Ried M, Bleicher S, Schamberger T, Blochberger I, Hofmann H-S, et al. EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients. Lung Cancer. 2022;167:73-77.

Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment.

Xie H, Sun Z, Xiao X, Liu D, Qi H, Tian G, Chen M, Chen L, Su XC. Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment. Stem Cells Transl Med. 2022.

'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.

Simkin D, Ambrosi C, Marshall KA, Williams LA, Eisenberg J, Gharib M, Dempsey GT, George AL, McManus OB, Kiskinis E. 'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies. Trends Pharmacol Sci. 2022;43(5):392-405.

Engineered three-dimensional cardiac tissues maturing in a rotating wall vessel bioreactor remodel diseased hearts in rats with myocardial infarction.

Nakazato T, Kawamura T, Uemura T, Liu L, Li J, Sasai M, Harada A, Ito E, Iseoka H, Toda K, et al. Engineered three-dimensional cardiac tissues maturing in a rotating wall vessel bioreactor remodel diseased hearts in rats with myocardial infarction. Stem Cell Reports. 2022.

Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells.

Zhu Y, Zhang Z, Fan N, Huang K, Li H, Gu J, Zhang Q, Ouyang Z, Zhang T, Tang J, et al. Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells. Stem Cell Reports. 2022.

Auxilin regulates intestinal stem cell proliferation through EGFR.

Zhao H, Ren X, Kong R, Shi L, Li Z, Wang R, Ma R, Zhao H, Liu F, Chang HC, et al. Auxilin regulates intestinal stem cell proliferation through EGFR. Stem Cell Reports. 2022.

Genome-wide screening for genes involved in the epigenetic basis of fragile X syndrome.

Vershkov D, Yilmaz A, Yanuka O, Nielsen ALade, Benvenisty N. Genome-wide screening for genes involved in the epigenetic basis of fragile X syndrome. Stem Cell Reports. 2022.

Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells.

Janesick A, Scheibinger M, Benkafadar N, Kirti S, Heller S. Avian auditory hair cell regeneration is accompanied by JAK/STAT-dependent expression of immune-related genes in supporting cells. Development. 2022.

Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway.

Qiu L, Cai J, Zhang N, Ma L, Fan F-Y, Li X-M. Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway. Tissue Cell. 2022;76:101791.

Generation of αMHC-EGFP knock-in in human pluripotent stem cell line, SNUe003-A-3 using CRISPR/Cas9-based gene targeting.

Lee HMyoung, Kim A-H, Hwang S, Jung J, Seol H, Sung JJea, Jeong SMin, Choi YMin, Jun JKwan, Kim H-S, et al. Generation of αMHC-EGFP knock-in in human pluripotent stem cell line, SNUe003-A-3 using CRISPR/Cas9-based gene targeting. Stem Cell Res. 2022;61:102779.

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging.

Gabriele M, Brandão HB, Grosse-Holz S, Jha A, Dailey GM, Cattoglio C, Hsieh T-HS, Mirny L, Zechner C, Hansen AS. Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. Science. 2022:eabn6583.

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Alvarez-Buylla A, Cebrián-Silla A, Sorrells SF, Nascimento MAssis, Paredes MF, García-Verdugo JManuel, Yang Z, Huang EJ. Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis". Science. 2022;376(6590):eabn8861.

Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus.

Zhang F, Meier AB, Sinnecker D, Engelhardt S, Lipp P, Laugwitz K-L, Dorn T, Moretti A. Generation of heterozygous (MRli003-A-5) and homozygous (MRli003-A-6) voltage-sensing knock-in human iPSC lines by CRISPR/Cas9 editing of the AAVS1 locus. Stem Cell Res. 2022;61:102785.

Real-time imaging of enzymatic degradation of pretreated maize internodes reveals different cell types have different profiles.

Leroy A, Devaux M-F, Fanuel M, Chauvet H, Durand S, Alvarado C, Habrant A, Sandt C, Rogniaux H, Paës G, et al. Real-time imaging of enzymatic degradation of pretreated maize internodes reveals different cell types have different profiles. Bioresour Technol. 2022:127140.

Extracellular vesicles and their microRNA cargo in ischaemic stroke.

Fullerton JL, Cosgrove CC, Rooney RA, Work LM. Extracellular vesicles and their microRNA cargo in ischaemic stroke. J Physiol. 2022.

Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway.

Tsao A-N, Chuang Y-S, Lin Y-C, Su Y, Chao T-C. Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway. Oncol Rep. 2022;47(5).

Limitations and challenges of direct cell reprogramming in vitro and in vivo.

Zhang Y-X, Chen S-L, Li Y-M, Zheng Y-W. Limitations and challenges of direct cell reprogramming in vitro and in vivo. Histol Histopathol. 2022:18458.

Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity.

Nguyen KA, Keith MJ, Keysar SB, Hall SC, Bimali A, Jimeno A, Wang X-J, Young CD. Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity. Mol Carcinog. 2022.

Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model.

Huang Y, Motta E, Nanvuma C, Kuhrt LD, Yuan Y, Xia P, Lubas M, Zhu S, Schnauss M, Qazi N, et al. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model. Cell Rep. 2022;39(2):110670.

Exosomes: A promising therapeutic strategy for intervertebral disc degeneration.

Wang C, Guo S, Gu Q, Wang X, Long L, Xiao C, Xie M, Shen H, Li S. Exosomes: A promising therapeutic strategy for intervertebral disc degeneration. Exp Gerontol. 2022:111806.

Gene expression profiles and cytokine environments determine the in vitro proliferation and expansion capacities of human hematopoietic stem and progenitor cells.

Dircio-Maldonado R, Castro-Oropeza R, Flores-Guzmán P, Cedro-Tanda A, Beltran-Anaya FOmar, Hidalgo-Miranda A, Mayani H. Gene expression profiles and cytokine environments determine the in vitro proliferation and expansion capacities of human hematopoietic stem and progenitor cells. Hematology. 2022;27(1):476-487.

Mechanical feedback defines organizing centers to drive digit emergence.

Parada C, Banavar SP, Khalilian P, Rigaud S, Michaut A, Liu Y, Joshy DManjaly, Campàs O, Gros J. Mechanical feedback defines organizing centers to drive digit emergence. Dev Cell. 2022;57(7):854-866.e6.

A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis.

Martin ET, Blatt P, Nguyen E, Lahr R, Selvam S, Yoon HAh M, Pocchiari T, Emtenani S, Siekhaus DE, Berman A, et al. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Dev Cell. 2022;57(7):883-900.e10.

Programming hydrogels to probe spatiotemporal cell biology.

Qazi TH, Blatchley MR, Davidson MD, F Yavitt M, Cooke ME, Anseth KS, Burdick JA. Programming hydrogels to probe spatiotemporal cell biology. Cell Stem Cell. 2022.

The response of a human hematopoietic cell line to trehalose-loaded liposomes and their effect on post-thaw membrane integrity.

Scott KL, William N, Acker JP. The response of a human hematopoietic cell line to trehalose-loaded liposomes and their effect on post-thaw membrane integrity. Cryobiology. 2022.

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes .

Yue X, Liu S-L, Guo J-N, Meng T-G, Zhang X-R, Li H-X, Song C-Y, Wang Z-B, Schatten H, Sun Q-Y, et al. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes . Aging (Albany NY). 2022;14(undefined).

Intradiscal Injection of Autologous Discogenic Cells in Patients with Discectomy: A Prospective Clinical Study of Its Safety and Feasibility.

Xuan A, Ruan D, Wang C, He Q, Wang D, Hou L, Zhang C, Li C, Ji W, Wen T, et al. Intradiscal Injection of Autologous Discogenic Cells in Patients with Discectomy: A Prospective Clinical Study of Its Safety and Feasibility. Stem Cells Transl Med. 2022.

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April 4 - April 10, 2022