Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

Zhou Y, Zheng R, Liu S, Disoma C, Du A, Li S, Chen Z, Dong Z, Zhang Y, Li S, et al. Host E3 ligase HUWE1 attenuates the pro-apoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation. J Biol Chem. 2022:101584.