Stembook Sections:
Cellular and nuclear reprogramming »
  • Inducing pluripotency
  • Stem cells in animal models of regeneration
  • Small RNAs – their biogenesis, regulation and function in embryonic stem cells
Ectoderm specification and differentiation »
  • The cranial sensory nervous system: specification of sensory progenitors and placodes
  • Tooth organogenesis and regeneration
  • Melanocyte stem cells
Endoderm specification and differentiation »
  • Pancreatic stem cells
  • Specification and patterning of the respiratory system
  • Liver development
Epigenetics »
  • Epigenetic mechanisms controlling mesodermal specification
  • Imaging chromatin in embryonic stem cells
  • Epigenetic silencing during early lineage commitment
Genomics and proteomics »
  • Proteomic studies of stem cells
  • Genome-wide transcription factor localization and function in stem cells
  • The pluripotent transcriptome
Germ cell and somatic stem cell biology in reproduction »
  • Regulation of spermatogonia
  • piRNA function in germline development
  • The role of microRNAs in germline differentiation
Manufacturing »
  • Regulatory challenges for the manufacture and scale-out of autologous cell therapies
  • From production to patient: challenges and approaches for delivering cell therapies
Mesoderm specification and differentiation »
  • Epigenetic mechanisms controlling mesodermal specification
  • Mouse kidney development
  • Adult mesenchymal stem cells
Niche biology, homing, and migration »
  • Hematopoietic stem cell trafficking
  • The neural stem cell microenvironment
Renewal »
  • Aging and stem cell renewal
  • Quiescent stem cells in the niche
  • Mechanisms regulating stem cell polarity and the specification of asymmetric divisions
Stem cell immunology »
  • Immunologic targeting of the cancer stem cell
  • Immunological considerations for cell therapy using human embryonic stem cell derivatives
  • Mouse models of graft-versus-host disease
Therapeutic prospects »
  • The hematopoietic stem cell niche
  • Medical applications of epidermal stem cells
  • Mesenchymal stromal cells as a drug delivery system
Tissue engineering »
  • Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery
  • Autologous approaches to tissue engineering
  • Flow perfusion culture of mesenchymal stem cells for bone tissue engineering

News & Commentaries

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Cancer Stem Cells Use “Normal” Genes in Abnormal Ways

colorado news

Denver, CO, USA – CDK1 is a “normal” protein – its presence drives cells through the cycle of replication. And MHC Class I molecules are “normal” as well – they present bits of proteins on the surfaces of cells for examination by the immune system. But a University of Colorado Cancer Center study published in the journal Cancer Research shows that a population of cancer cells marked by MHC Class I molecules and high CDK1 is anything but normal.

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Cells in 'Little Brain' Have Distinctive Metabolic Needs

emory news

Atlanta, GA, USA – Cells' metabolic needs are not uniform across the brain, researchers have learned. "Knocking out" an enzyme that regulates mitochondria, cells' miniature power plants, specifically blocks the development of the mouse cerebellum more than the rest of the brain. The results are scheduled for publication in Science Advances.