News & Commentaries

New Method to Purify Cell Rypes to High Purity

StemBook: Graphical representation of the GateID method (stem cells)

Utrecht, The Netherlands – Researchers from the group of Alexander van Oudenaarden and Eelco de Koning have developed GateID, a new method that can highly purify a cell type of interest from a tissue, without the use of antibodies or a genetic reporter. Thereby, GateID allows to isolate a variety of cell types, such as stem cells, in order to study them in more detail. The researchers have published their results in the scientific journal Cell.

Stem Cell Studies Offer Hope for Childhood Neurological Condition

StemBook: Stem Cell Studies Offer Hope for Childhood Neurological Condition (stem cells)
As Both Therapy and Tool for Drug Discovery, Stem Cells Present Parallel Opportunities for Treatment

San Francisco, CA, USA – Two new studies by an international team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease (PMD), a rare genetic condition affecting boys that can be fatal before 10 years of age.

Possible Therapeutic Target For Slow Healing Of Aged Muscles Discovered

STEMBOOK: Possible Therapeutic Target For Slow Healing Of Aged Muscles Discovered by Liangji Li

Washington, DC, USA – An age-related decline in recovery from muscle injury can be traced to a protein that suppresses the special ability of muscle stem cells to build new muscles, according to work from a team of current and former Carnegie biologists led by Chen-Ming Fan and published in Nature Metabolism.

How Transcription Factor Fluctuations Affect the Fate of Stem Cells

STEMBOOK: How transcription factor fluctuations affect the fate of stem cells EPFL

Lausanne, Switzerland – How do temporal variations in protein concentrations affect biology? It’s a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and significant role on biological processes.

Engineered Killer T Cells Could Provide Long-lasting Immunity Against Cancer

STEMBOOK: Engineered killer T cells could provide long-lasting immunity against cancer Lili Yang UCLA
UCLA researchers use stem cells to engineer cells that attack human tumors in mice

Los Angeles, CA, USA – They've been called the "special forces" of the immune system: invariant natural killer T cells. Although there are relatively few of them in the body, they are more powerful than many other immune cells. In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals.

Suntanner, Heal Thyself: Exosome Therapy May Enable Better Repair of Sun, Age-Damaged Skin

STEMBOOK: Monolayer dermal fibroblasts were cultured into spheroids, then exosomes were collected and delivered by a needle-free injector for skin aging treatment

Raleigh, NC, USA – In the future, you could be your very own fountain of youth – or at least your own skin repair reservoir. In a proof-of-concept study, researchers from North Carolina State University have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments currently in use. Additionally, the nanometer-sized exosomes can be delivered to the target cells via needle-free injections.

Gene Editing Enables Researchers to Correct Mutation in Muscle Stem Cells in Muscular Dystrophy Mouse Model

STEMBOOK: Gene Editing Enables Researchers to Correct Mutation in Muscle Stem Cells in Muscular Dystrophy Mouse Model Stem Cells

Colombia, MO, USA – Duchenne muscular dystrophy (DMD) is a rare but devastating genetic disorder that causes muscle loss and physical impairments. Researchers at the University of Missouri School of Medicine have shown in a mouse study that the powerful gene editing technique known as CRISPR may provide the means for lifelong correction of the genetic mutation responsible for the disorder.

Alzheimer's Disease Risk Gene APOE4 Impairs Function of Brain Immune Cells

STEMBOOK: Alzheimer's disease risk gene APOE4 impairs function of brain immune cells

Joensuu, Finland – A study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD. The results were published in Stem Cell Reports.

Stem Cell Researchers Reactivate 'Back-Up Genes' in the Lab

StemBook: Stem cell researchers reactivate 'back-up genes' in the lab (stem cells)

Leuven, Belgium – Vincent Pasque and his team at KU Leuven have unravelled parts of a mechanism that may one day help to treat Rett syndrome and other genetic disorders linked to the X chromosome. Women and most female mammals have two X chromosomes, but only one of these is active in any given cell. This active X chromosome is selected through a flip-of-the-coin process in the very early stages of embryonic development: each chromosome has a 50/50 chance of remaining active and getting to express its genes, or to be inactivated through a process called X chromosome inactivation.

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