News & Commentaries

Bacteria Made to Mimic Cells, Form Communities

[STEMBOOK]: Bacteria made to mimic cells, form communities
Rice University synthetic biologists prompt dividing bacteria to differentiate like stem cells

Houston, TX, USA – Rice University scientists have found a way to engineer a new kind of cell differentiation in bacteria, inspired by a naturally occurring process in stem cells. They have created a genetic circuit able to produce genetically distinguished cells of Escherichia coli as the bacterium divides. By controlling this process, it is possible to create diverse communities of microbes that exhibit complex, non-native behaviors.

Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes

[STEMBOOK]: Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes (Stemcells)
By reaching stem cells at the tumor’s root, multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice

San Diego, CA, USA – Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery. Even when chemotherapy and radiation successfully destroy the bulk of a patient’s glioblastoma cells, they may not affect the cancer stem cells. This small population of tumor cells have the capacity to grow and multiply indefinitely, and can lead to tumor recurrence.

UCLA Study Links Progenitor Cells to Age-Related Prostate Growth

StemBook: UCLA study links progenitor cells to age-related prostate growth (stem cells)

Los Angeles, CA, USA – The prostates of older mice contain more luminal progenitor cells – cells capable of generating new prostate tissue – than the prostates of younger mice, UCLA researchers have discovered. The observation, published in Cell Reports, helps explain why, as people age, the prostate tends to grow, leading to an increased risk for prostate cancer and other conditions.

Mount Sinai Researchers Make Immunotherapy Work for Rreatment-Resistant Lymphoma

New York, NY, USA – Mount Sinai researchers have developed a way to use immunotherapy drugs against treatment-resistant non-Hodgkin's lymphomas for the first time by combining them with stem cell transplantation, an approach that also dramatically increased the success of the drugs in melanoma and lung cancer, according to a study published in Cancer Discovery in August.

Old Cells, New Tricks – Important Clue to AML Diagnosis and Cure Discovered

Clayton, Australia – Around 22,000 people will be diagnosed this year in the US with acute myeloid leukemia (AML), the second most common type of leukemia diagnosed in adults and children, and the most aggressive of the leukemias. Less than one third of AML patients survive five years beyond diagnosis.

Assessing Direct-to-Consumer Stem Cell Clinics

Phoenix, AZ, USA – This direct-to-consumer stem cell marketplace has come under increasing scrutiny, but relatively little is known about the clinics or how the treatments they offer align with the expertise of their practitioners. Investigators now offer a detailed characterization of nearly 170 stem cell businesses across Arizona, California, Colorado, Nevada, New Mexico, and Utah, where about one-third of US stem cell clinics are located.

Targeting a Blood Stem Cell Subset Shows Lasting, Therapeutically Relevant Gene Editing

[STEMBOOK]: Targeting a blood stem cell subset shows lasting, therapeutically relevant gene editing, STEMCELLS

Seattle, WA, USA – In a paper published in the July 31 issue of Science Translational Medicine, researchers at Fred Hutchinson Cancer Research Center used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, including sickle cell disease and beta-thalassemia.

Uncovering Secrets of Bone Marrow Cells and How They Differentiate

StemBook: Uncovering secrets of bone marrow cells and how they differentiate (stem cells)

Birmingham, AL, USA – Bone marrow contains biological factories, which pump out billions of new blood cells daily. The non-blood cells that maintain this production also have the potential to produce bone, fat and cartilage. This output all starts from stem cells that have the ability to differentiate into various types of cells.

Stem Cell Research Sheds New Light on the Skin

STEMBOOK: Stem Cell Research Sheds New Light on the Skin

Copenhagen, Denmark – For the first time, researchers from the University of Copenhagen have studied and outlined the development of sebaceous glands in the skin. The study provides greater insight into the development and maintenance of the skin and how cancer mutations affect the behaviour of stem cells and was published in Nature Cell Biology.

Laboratory Study Paves Way for New Approach to Treating Hair Loss in Humans

Laboratory study paves way for new approach to treating hair loss in humans

Yokohama, Japan – Japanese scientists have developed an efficient method of successfully generating hair growth in nude mice. The new method can be scaled up and therefore shows great potential for clinical applications in human hair regenerative therapy. Their findings were published on May 9, 2019 in Biomaterials.